:root {
  color-scheme: light;
  --ink: #102f36;
  --navy: #073b57;
  --teal: #087e80;
  --green: #2d9a74;
  --mint: #eaf8f2;
  --mint-2: #f4fbf8;
  --yellow: #dafa8a;
  --muted: #526b72;
  --line: #d8e7e1;
  --line-dark: #9fbab5;
  --paper: #ffffff;
  --soft: #f4f8f7;
  --soft-2: #e8f2ef;
  --danger: #9f1d1d;
  --warning: #725300;
  --success: #145c34;
  --shadow: 0 18px 46px rgba(5, 52, 57, 0.08);
  --shadow-small: 0 8px 24px rgba(5, 52, 57, 0.06);
  font-family: Arial, Helvetica, sans-serif;
}

* { box-sizing: border-box; }
[hidden] { display: none !important; }
html { background: #f6fbf9; }
body { margin: 0; min-width: 320px; min-height: 100vh; color: var(--ink); background: radial-gradient(circle at 8% 0%, rgba(45,154,116,.12), transparent 26%), linear-gradient(180deg, #fbfdfc 0%, #f1f8f5 100%); }
button, input, select { font: inherit; }
button { cursor: pointer; }
h1, h2, h3, p { margin-top: 0; }
h1 { margin-bottom: 3px; color: var(--navy); font-family: Georgia, "Times New Roman", serif; font-size: clamp(1.35rem, 2vw, 1.85rem); font-weight: 700; letter-spacing: -.025em; }
h2 { margin: 4px 0 0; color: var(--navy); font-family: Georgia, "Times New Roman", serif; font-size: clamp(1.25rem, 2vw, 1.58rem); font-weight: 700; letter-spacing: -.015em; }
h3 { margin: 0; color: var(--navy); font-family: Georgia, "Times New Roman", serif; font-size: 1.06rem; font-weight: 700; }

.topbar { min-height: 86px; display: flex; align-items: center; gap: 15px; padding: 16px clamp(18px, 4vw, 54px); border-bottom: 1px solid rgba(7,59,87,.12); background: rgba(251,253,252,.92); backdrop-filter: blur(12px); position: sticky; top: 0; z-index: 20; box-shadow: 0 10px 28px rgba(5,52,57,.045); }
.topbar p { margin: 0; color: var(--muted); font-size: .86rem; }
.topbar-actions { display: flex; margin-left: auto; gap: 8px; }
.brand-mark { display: grid; place-items: center; width: 64px; height: 48px; color: var(--white, #fff); border: 1px solid rgba(255,255,255,.18); border-radius: 14px; background: linear-gradient(135deg, var(--navy), var(--teal)); box-shadow: 0 10px 25px rgba(7,59,87,.18); font-size: .69rem; font-weight: 900; letter-spacing: .13em; }
.brand-owner { display: block; margin-bottom: 2px; color: var(--teal); font-size: .63rem; font-weight: 850; letter-spacing: .14em; line-height: 1.2; text-transform: uppercase; }
main { width: min(1580px, 100%); margin: 0 auto; padding: 26px clamp(14px, 3vw, 46px) 60px; }

.workflow-overview { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 12px; margin-bottom: 18px; }
.workflow-overview article { min-height: 112px; padding: 18px; border: 1px solid rgba(7,59,87,.1); border-radius: 22px; background: rgba(255,255,255,.78); box-shadow: var(--shadow-small); }
.workflow-overview span { display: inline-flex; margin-bottom: 12px; color: var(--green); font-size: .72rem; font-weight: 900; letter-spacing: .14em; }
.workflow-overview strong { display: block; color: var(--navy); font-family: Georgia, "Times New Roman", serif; font-size: 1.08rem; }
.workflow-overview p { margin: 6px 0 0; color: var(--muted); font-size: .78rem; line-height: 1.45; }

.workspace-tabs { position: sticky; top: 96px; z-index: 30; width: max-content; display: flex; justify-content: flex-end; margin: 0 0 12px auto; pointer-events: none; }
.workspace-menu-button { min-width: 225px; min-height: 46px; display: grid; grid-template-columns: auto 1fr auto; align-items: center; gap: 10px; padding: 0 14px; border: 1px solid rgba(7,59,87,.14); border-radius: 999px; color: #fff; background: linear-gradient(135deg, var(--navy), var(--teal)); box-shadow: 0 12px 28px rgba(5,52,57,.18); pointer-events: auto; text-align: left; }
.workspace-menu-button > span:first-child { color: rgba(255,255,255,.72); font-size: .64rem; font-weight: 850; letter-spacing: .08em; text-transform: uppercase; }
.workspace-menu-button strong { font-size: .82rem; }
.workspace-menu-chevron { font-size: 1.15rem; transition: transform .18s ease; }
.workspace-menu-button[aria-expanded="true"] .workspace-menu-chevron { transform: rotate(180deg); }
.workspace-menu { position: absolute; top: calc(100% + 7px); right: 0; width: 270px; display: grid; gap: 5px; padding: 8px; border: 1px solid rgba(7,59,87,.13); border-radius: 17px; background: rgba(251,253,252,.98); box-shadow: 0 20px 50px rgba(5,52,57,.22); backdrop-filter: blur(14px); pointer-events: auto; }
.workspace-menu button { min-height: 43px; display: flex; align-items: center; gap: 11px; padding: 0 13px; border: 1px solid transparent; border-radius: 11px; color: var(--navy); background: transparent; font-size: .8rem; font-weight: 800; text-align: left; }
.workspace-menu button span { width: 28px; color: var(--green); font-size: .69rem; letter-spacing: .08em; }
.workspace-menu button:hover, .workspace-menu button.active { border-color: rgba(45,154,116,.2); background: var(--mint); }
.workspace-menu button.active { color: var(--navy); background: var(--mint); }
.workspace-menu button.active::after { margin-left: auto; color: var(--green); content: "✓"; font-size: .9rem; font-weight: 950; }
.workspace-menu-all { color: #fff !important; background: linear-gradient(135deg, var(--navy), var(--teal)) !important; }
.workspace-menu-all span { color: var(--yellow) !important; font-size: 1rem !important; }
.workspace-menu-divider { height: 1px; margin: 2px 6px; background: rgba(7,59,87,.1); }
.workspace-tabs > a { min-height: 40px; display: none; align-items: center; justify-content: center; padding: 0 14px; border-radius: 999px; color: #fff; background: linear-gradient(135deg, var(--navy), var(--teal)); font-size: .78rem; font-weight: 800; text-decoration: none; }
.workspace-tabs:has(> a) { width: 240px; align-items: stretch; flex-direction: column; gap: 5px; padding: 6px; border: 1px solid rgba(7,59,87,.13); border-radius: 18px; background: rgba(251,253,252,.98); box-shadow: var(--shadow-small); pointer-events: auto; }
.workspace-tabs:has(> a) > a.active, .workspace-tabs:has(> a):hover > a, .workspace-tabs:has(> a):focus-within > a { display: flex; }
.workspace-tabs:has(> a):hover > a:not(.active), .workspace-tabs:has(> a):focus-within > a:not(.active) { color: var(--navy); background: var(--mint-2); }
.workspace-section { scroll-margin-top: 150px; }

body.workspace-ready main > #configuracion, body.workspace-ready main > #proyecto, body.workspace-ready main > #datos, body.workspace-ready main > #resultados { display: none !important; }
body.workspace-ready.workspace-show-configuracion main > #configuracion, body.workspace-ready.workspace-show-proyecto main > #proyecto, body.workspace-ready.workspace-show-datos main > #datos, body.workspace-ready.workspace-show-resultados main > #resultados, body.workspace-ready.workspace-show-figuras main > #resultados, body.workspace-ready.workspace-show-informe main > #resultados { display: block !important; }

.stats-ticker { min-height: 48px; display: grid; grid-template-columns: auto minmax(0, 1fr); align-items: stretch; margin-bottom: 18px; overflow: hidden; border: 1px solid rgba(7,59,87,.2); border-radius: 14px; background: #062f37; box-shadow: 0 12px 28px rgba(5,52,57,.12); }
.ticker-label { display: flex; align-items: center; padding: 0 14px; color: #082f38; background: var(--yellow); font-size: .68rem; font-weight: 950; letter-spacing: .11em; white-space: nowrap; }
.ticker-viewport { min-width: 0; display: flex; align-items: center; overflow: hidden; }
.ticker-track { width: max-content; display: flex; align-items: center; gap: 34px; padding-left: 34px; color: #bdf4ca; font-family: "Cascadia Mono", Consolas, monospace; font-size: .75rem; letter-spacing: .035em; white-space: nowrap; animation: bioaox-ticker 48s linear infinite; }
.ticker-track span::before { margin-right: 10px; color: var(--yellow); content: "◆"; }
.stats-ticker:hover .ticker-track { animation-play-state: paused; }
@keyframes bioaox-ticker { from { transform: translateX(0); } to { transform: translateX(-50%); } }

.panel { background: rgba(255,255,255,.88); border: 1px solid rgba(7,59,87,.11); border-radius: 18px; box-shadow: var(--shadow); }
.setup-panel, .data-panel, .project-panel, .recommendation-panel, .metrics-panel, .table-panel, .chart-panel, .correlation-panel, .scientific-basis, .analysis-options-panel, .conclusion-panel, .multi-results-panel, .report-builder { padding: 20px; }
.data-panel { margin-top: 18px; border-color: rgba(7,59,87,.18); }
.project-panel { margin-top: 18px; background: linear-gradient(135deg, #ffffff, #f1faf6); }
.project-heading { margin-bottom: 12px; }
.project-heading .help-text { max-width: 820px; margin-top: 7px; }
.assay-workspace-tabs { display: grid; grid-template-columns: repeat(5, minmax(130px, 1fr)); gap: 8px; }
.assay-tab { min-height: 72px; display: grid; align-content: center; gap: 4px; padding: 11px 13px; border: 1px solid rgba(7,59,87,.16); border-radius: 14px; background: #fff; color: var(--ink); text-align: left; transition: transform .18s ease, box-shadow .18s ease, border-color .18s ease; }
.assay-tab:hover { transform: translateY(-1px); border-color: rgba(45,154,116,.42); background: var(--mint-2); box-shadow: var(--shadow-small); }
.assay-tab.active { color: #fff; background: linear-gradient(135deg, var(--navy), var(--teal)); border-color: transparent; box-shadow: 0 16px 32px rgba(7,59,87,.18); }
.assay-tab strong { font-size: .84rem; }
.assay-tab span { font-size: .7rem; color: var(--muted); }
.assay-tab.active span { color: #ddd; }
.assay-tab.analyzed:not(.active) { box-shadow: inset 0 -4px 0 var(--green); }
.project-actions { display: flex; align-items: center; gap: 14px; margin-top: 12px; }
.project-actions .validation { margin: 0; }
.project-file-card { display: grid; grid-template-columns: minmax(0, 1fr) auto; align-items: center; gap: 12px 18px; margin-top: 14px; padding: 15px 16px; border: 1px solid rgba(45,154,116,.24); border-radius: 16px; background: rgba(255,255,255,.8); }
.project-file-card h3 { margin-top: 4px; }
.project-file-controls { display: flex; align-items: center; gap: 8px; flex-wrap: wrap; justify-content: flex-end; }
.project-file-card .validation { grid-column: 1 / -1; margin: 0; }
.section-heading, .panel-title-row, .results-title { display: flex; align-items: flex-start; justify-content: space-between; gap: 18px; }
.section-heading { margin-bottom: 18px; }
.panel-title-row { align-items: center; margin-bottom: 13px; }
.panel-title-row > div > .legend-note { display: block; margin-top: 4px; text-align: left; }
.eyebrow { color: var(--teal); font-size: .7rem; text-transform: uppercase; letter-spacing: .15em; font-weight: 850; }
.count-badge, .route-badge { display: inline-flex; align-items: center; min-height: 30px; border: 1px solid rgba(7,59,87,.18); border-radius: 999px; padding: 4px 11px; background: #fff; color: var(--navy); font-size: .78rem; font-weight: 800; white-space: nowrap; }
.route-badge.recommended { background: var(--navy); color: var(--paper); border-color: var(--navy); }

.field-grid { display: grid; gap: 12px; }
.setup-grid { grid-template-columns: 1.2fr 1.25fr .65fr; }
label > span { display: block; margin-bottom: 6px; color: var(--muted); font-size: .86rem; font-weight: 650; }
input, select { width: 100%; min-height: 42px; padding: 0 12px; color: var(--ink); background: var(--paper); border: 1px solid rgba(7,59,87,.18); border-radius: 10px; outline: none; }
input:focus, select:focus { border-color: var(--green); box-shadow: 0 0 0 3px rgba(45,154,116,.14); }
.precalculated-row { max-width: 320px; margin: 4px 0 14px; }
.is-hidden { display: none !important; }

.calibration-card { margin-top: 16px; padding: 0; border: 1px solid rgba(7,59,87,.1); border-radius: 16px; background: var(--soft); overflow: hidden; }
.calibration-card summary { display: flex; justify-content: space-between; align-items: center; gap: 16px; padding: 13px 14px; cursor: pointer; list-style: none; }
.calibration-card summary::-webkit-details-marker { display: none; }
.calibration-card summary strong { display: block; margin-top: 3px; font-family: Georgia, "Times New Roman", serif; }
.calibration-card[open] summary { border-bottom: 1px solid rgba(7,59,87,.1); }
.equation-chip { border: 1px solid rgba(7,59,87,.16); border-radius: 10px; padding: 6px 9px; background: var(--paper); font-family: "Cascadia Mono", Consolas, monospace; font-size: .78rem; white-space: nowrap; }
.calibration-grid { display: grid; grid-template-columns: repeat(6, minmax(125px, 1fr)); gap: 10px; padding: 14px; }
.formula-strip { display: flex; flex-wrap: wrap; gap: 8px; padding: 0 14px 12px; }
.formula-strip span { padding: 6px 8px; border: 1px solid rgba(7,59,87,.1); border-radius: 9px; background: var(--paper); font-family: "Cascadia Mono", Consolas, monospace; font-size: .75rem; }
.calibration-note { margin: 0; padding: 0 14px 14px; color: var(--muted); font-size: .73rem; }

.data-heading { align-items: flex-end; }
.help-text { margin: 6px 0 0; color: var(--muted); font-size: .78rem; line-height: 1.4; }
.grid-toolbar { display: flex; flex-wrap: wrap; justify-content: flex-end; gap: 7px; }
.grid-shell { width: 100%; max-height: 510px; overflow: auto; border: 1px solid rgba(7,59,87,.16); border-radius: 14px; background: var(--paper); outline: none; }
.grid-shell:focus-within { box-shadow: 0 0 0 3px rgba(45,154,116,.14); }
.data-grid { min-width: 980px; table-layout: fixed; }
.data-grid thead { position: sticky; top: 0; z-index: 4; }
.data-grid th { height: 46px; padding: 5px 7px; background: var(--soft-2); color: var(--navy); border-right: .5px solid var(--line); border-bottom: 1px solid rgba(7,59,87,.16); text-align: center; text-transform: none; letter-spacing: 0; font-size: .8rem; }
.data-grid th.row-number, .data-grid td.row-number { width: 42px; text-align: center; background: var(--soft-2); color: var(--muted); }
.data-grid th.use-column, .data-grid td.use-column { width: 50px; text-align: center; }
.data-grid th.status-column, .data-grid td.status-column { width: 225px; }
.data-grid th.delete-column, .data-grid td.delete-column { width: 42px; text-align: center; }
.data-grid th.unit-column { padding: 3px 5px; }
.data-grid th.unit-column > span { display: block; margin-bottom: 2px; }
.data-grid th select { min-height: 24px; width: auto; padding: 0 4px; font-size: .68rem; background: var(--paper); }
.data-grid td { position: relative; height: 35px; padding: 0; border-right: .5px solid #e6e7e8; border-bottom: .5px solid #e6e7e8; text-align: left; }
.data-grid td input[type="text"] { height: 34px; min-height: 34px; padding: 4px 7px; border: 0; border-radius: 0; box-shadow: none; font-family: Arial, Helvetica, sans-serif; font-size: .86rem; }
.data-grid td input[type="text"]:focus { outline: 2px solid var(--green); outline-offset: -2px; }
.data-grid td input[type="checkbox"] { width: 16px; min-height: auto; accent-color: var(--green); }
.editable-cell .fill-handle { position: absolute; right: 2px; bottom: 2px; width: 9px; height: 9px; border: 1px solid #fff; border-radius: 50%; background: var(--green); box-shadow: 0 0 0 1px rgba(7,59,87,.18); cursor: crosshair; opacity: 0; transform: scale(.8); transition: opacity .14s ease, transform .14s ease; touch-action: none; }
.editable-cell:hover .fill-handle, .editable-cell:focus-within .fill-handle { opacity: 1; transform: scale(1); }
.editable-cell.fill-source { box-shadow: inset 0 0 0 2px var(--green); }
.editable-cell.fill-preview { background: rgba(45,154,116,.12); box-shadow: inset 0 0 0 2px rgba(45,154,116,.42); }
body.grid-fill-active { cursor: crosshair; user-select: none; }
.data-grid tr.excluded td { background: #f4f4f4; color: #888; }
.data-grid tr.outlier td.status-column { color: var(--warning); font-weight: 700; }
.status-text { display: inline-block; padding: 4px 7px; font-size: .78rem; line-height: 1.25; white-space: normal; }
.row-delete { width: 24px; height: 24px; padding: 0; border: 0; background: transparent; color: var(--muted); font-size: 1.05rem; }
.grid-footer { display: grid; grid-template-columns: minmax(220px, 1fr) minmax(260px, 1.3fr) auto; align-items: center; gap: 14px; margin-top: 11px; }
.grid-footer .help-text, .grid-footer .validation { margin: 0; }
.validation { min-height: 1.3em; color: var(--warning); font-size: .78rem; }
.validation.success { color: var(--success); }
.validation.error { color: var(--danger); }

.button { min-height: 38px; display: inline-flex; align-items: center; justify-content: center; padding: 0 14px; border: 1px solid rgba(7,59,87,.18); border-radius: 999px; background: var(--paper); color: var(--navy); font-size: .84rem; font-weight: 800; text-decoration: none; transition: transform .18s ease, box-shadow .18s ease, background .18s ease; }
.button:hover { transform: translateY(-1px); background: var(--mint-2); box-shadow: var(--shadow-small); }
.button.primary { min-height: 44px; padding: 0 22px; border-color: transparent; background: linear-gradient(135deg, var(--teal), var(--green)); color: var(--paper); box-shadow: 0 14px 30px rgba(45,154,116,.22); }
.button.primary:hover { background: linear-gradient(135deg, #066b70, #258b68); }
.button.secondary { background: var(--paper); }
.button.ghost { border-color: var(--line-dark); }
.button:disabled { opacity: .42; cursor: not-allowed; }

.results { margin-top: 30px; }
.results-title { align-items: center; margin-bottom: 14px; }
.overview-grid, .diagnostics-grid, .chart-grid, .analysis-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 16px; }
.diagnostics-grid, .chart-grid, .analysis-grid { margin-top: 16px; }
.recommendation-panel, .metrics-panel { min-height: 230px; }
.interpretation { padding: 14px; border-left: 4px solid var(--green); border-radius: 12px; background: var(--soft); font-size: .85rem; line-height: 1.55; }
.interpretation.significant { border-left-style: double; border-left-width: 5px; }
.empty-state { color: var(--muted); }
.method-notes { margin: 13px 0 0; padding-top: 9px; border-top: .6px solid var(--line); }
.method-notes div { display: flex; justify-content: space-between; gap: 12px; padding: 4px 0; }
.method-notes dt, .method-notes dd { margin: 0; font-size: .76rem; }
.method-notes dt { color: var(--muted); }
.method-notes dd { text-align: right; font-weight: 650; }
.metric-grid { display: grid; height: 100%; grid-template-columns: repeat(2, 1fr); gap: 10px; }
.metric { min-height: 88px; padding: 13px; border: 1px solid rgba(7,59,87,.1); border-radius: 14px; background: var(--paper); }

.scientific-basis { margin-top: 16px; }
.scientific-decision { margin: 0 0 14px; padding: 13px 15px; background: linear-gradient(90deg, #edf8f4, #fafdfc); border-left: 4px solid var(--green); border-radius: 12px; font-size: .9rem; line-height: 1.55; }
.basis-grid { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 8px; }
.basis-grid details { border: 1px solid rgba(7,59,87,.1); border-radius: 14px; background: var(--paper); overflow: hidden; }
.basis-grid summary { padding: 10px 11px; cursor: pointer; font-size: .84rem; font-weight: 700; }
.basis-grid p { margin: 0; padding: 0 11px 11px; color: var(--muted); font-size: .82rem; line-height: 1.5; }
.scientific-sources { margin: 12px 0 0; color: var(--muted); font-size: .78rem; line-height: 1.5; }
.scientific-sources a { color: var(--ink); text-underline-offset: 2px; }
.metric span { display: block; margin-bottom: 12px; color: var(--muted); font-size: .72rem; }
.metric strong { display: block; font-family: Georgia, "Times New Roman", serif; font-size: 1.55rem; }

.analysis-options-panel, .conclusion-panel { margin-top: 16px; }
.analysis-options { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 10px; margin-top: 14px; }
.analysis-option { position: relative; display: block; min-height: 180px; padding: 15px; border: 1px solid rgba(7,59,87,.14); border-radius: 16px; background: var(--paper); cursor: pointer; transition: transform .18s ease, box-shadow .18s ease, border-color .18s ease; }
.analysis-option:hover { transform: translateY(-1px); border-color: rgba(45,154,116,.38); background: #fafdfc; box-shadow: var(--shadow-small); }
.analysis-option.selected { border-color: var(--green); box-shadow: inset 0 0 0 1px var(--green); }
.analysis-option input { position: absolute; width: 1px; height: 1px; opacity: 0; pointer-events: none; }
.analysis-option-head { display: flex; align-items: flex-start; justify-content: space-between; gap: 9px; }
.analysis-option-title { color: var(--ink); font-family: Georgia, "Times New Roman", serif; font-size: .98rem; font-weight: 700; }
.fit-chip { display: inline-flex; min-height: 23px; align-items: center; padding: 3px 7px; border: .5px solid var(--line-dark); border-radius: 999px; color: var(--muted); background: var(--soft); font-size: .66rem; font-weight: 700; line-height: 1.2; text-align: center; }
.fit-chip.best { color: var(--paper); background: var(--navy); border-color: var(--navy); }
.fit-chip.caution { color: var(--warning); }
.analysis-option p { margin: 10px 0 0; color: var(--muted); font-size: .78rem; line-height: 1.45; }
.analysis-option .changes { padding-top: 9px; border-top: .5px solid var(--line); color: var(--ink); }
.analysis-choice-footer { display: grid; grid-template-columns: auto 1fr; align-items: center; gap: 14px; margin-top: 12px; }
.choice-impact { margin: 0; color: var(--muted); font-size: .79rem; line-height: 1.45; }
.conclusion-panel { border-color: rgba(45,154,116,.28); background: linear-gradient(90deg, #fff, #f0faf6); }
.conclusion-text { margin: 0; font-size: .92rem; line-height: 1.65; }

.table-panel { min-width: 0; margin-top: 16px; }
.diagnostics-grid .table-panel, .analysis-grid .table-panel { margin-top: 0; }
.table-wrap { overflow-x: auto; border: 1px solid rgba(7,59,87,.1); border-radius: 14px; background: #fff; }
table { width: 100%; border-collapse: collapse; font-size: .79rem; }
th, td { padding: 10px 11px; border-bottom: .5px solid #e4e5e6; text-align: right; white-space: nowrap; }
th { background: var(--soft); color: var(--navy); font-size: .69rem; font-weight: 800; letter-spacing: .025em; text-transform: uppercase; }
th:first-child, td:first-child { text-align: left; }
tbody tr:last-child td { border-bottom: 0; }
tbody tr:hover { background: #fafafa; }
.table-empty { padding: 28px; color: var(--muted); text-align: center !important; }
.processed-wrap { max-height: 390px; overflow: auto; }
.processed-wrap thead, .posthoc-wrap thead { position: sticky; top: 0; z-index: 2; }
.posthoc-wrap { max-height: 390px; overflow: auto; }
.letter-chip { display: inline-grid; place-items: center; min-width: 27px; height: 24px; padding: 0 7px; border: 1px solid var(--teal); border-radius: 50%; background: var(--paper); color: var(--teal); font-weight: 800; }
.sig-yes { font-weight: 700; color: var(--ink); }
.sig-no { color: var(--muted); }
.quality-flag { color: var(--warning); font-weight: 700; }
.quality-ok { color: var(--muted); }
.small-action { min-height: 28px; padding: 0 8px; border: .5px solid var(--line-dark); background: var(--paper); font-size: .76rem; }

.chart-controls { display: grid; grid-template-columns: minmax(230px, 1fr) repeat(3, minmax(150px, .7fr)); align-items: end; gap: 12px; margin-top: 16px; padding: 14px 18px; background: var(--soft); }
.chart-controls h3 { margin-top: 4px; }
.chart-panel { min-width: 0; border: 0; box-shadow: none; }
.figure-download { min-height: 30px; padding: 0 9px; border-color: var(--line-dark); font-size: .76rem; font-weight: 600; }
.panel-actions, .figure-actions { display: flex; align-items: center; gap: 6px; flex-wrap: wrap; justify-content: flex-end; }
.chart { width: 100%; min-height: 420px; overflow-x: auto; overflow-y: hidden; background: var(--paper); }
.empty-chart { display: grid; place-items: center; border: .5px dashed var(--line); color: var(--muted); }
.chart svg { display: block; width: 100%; min-width: 650px; height: 420px; }
.chart text { font-family: var(--chart-font, Arial, Helvetica, sans-serif); }
.legend-note { color: var(--muted); font-size: .71rem; text-align: right; }

.figure-studio { margin-top: 24px; padding: 26px; border-color: rgba(45,154,116,.26); background: linear-gradient(135deg, rgba(255,255,255,.96), rgba(235,249,243,.9)); }
.figure-studio > .panel-title-row { margin-bottom: 20px; }
.figure-studio > .panel-title-row .help-text { max-width: 760px; margin-top: 8px; }
.figure-studio-controls { display: grid; grid-template-columns: repeat(auto-fit, minmax(230px, 1fr)); align-items: end; gap: 18px 16px; padding: 20px; border: 1px solid rgba(7,59,87,.12); border-radius: 15px; background: rgba(255,255,255,.82); }
.figure-studio-controls label { min-width: 0; display: grid; align-content: start; gap: 8px; }
.figure-studio-controls label > span { margin-bottom: 0; line-height: 1.35; }
.figure-studio-controls input, .figure-studio-controls select { min-height: 46px; }
.figure-studio-controls .button { min-width: 190px; min-height: 46px; justify-self: start; }
.figure-studio .interpretation { margin-top: 12px; }
.figure-studio-chart { min-height: 500px; margin-top: 12px; border: 1px solid rgba(7,59,87,.1); border-radius: 14px; }
.figure-studio-chart svg { min-width: 760px; height: 500px; }
.figure-caution { margin: 12px 0 0; padding: 12px 14px; border-left: 4px solid var(--teal); border-radius: 10px; color: var(--muted); background: rgba(255,255,255,.78); font-size: .8rem; line-height: 1.55; }
.figure-caution strong { color: var(--ink); }

.correlation-panel { margin-top: 16px; }
.correlation-controls { display: grid; grid-template-columns: repeat(5, minmax(140px, 1fr)); align-items: end; gap: 10px; padding: 13px; border: .5px solid var(--line); background: var(--soft); }
.correlation-controls .button { min-height: 40px; }
.pairing-note { margin: 9px 2px 0; color: var(--muted); font-size: .76rem; line-height: 1.45; }
.correlation-output { display: grid; grid-template-columns: minmax(260px, .62fr) minmax(0, 1.38fr); align-items: start; gap: 14px; margin-top: 14px; }
.correlation-output .interpretation { align-self: start; }
.correlation-comparison { grid-column: 1; }
.correlation-comparison th, .correlation-comparison td { white-space: normal; vertical-align: top; }
.correlation-comparison th:nth-child(2), .correlation-comparison td:nth-child(2), .correlation-comparison th:nth-child(3), .correlation-comparison td:nth-child(3) { text-align: right; white-space: nowrap; }
.correlation-comparison .selected-method { background: #efefef; font-weight: 650; }
.correlation-conclusion { grid-column: 1 / -1; margin: 0; padding: 13px 15px; border-left: 4px solid var(--green); border-radius: 12px; background: var(--soft); font-size: .85rem; line-height: 1.55; }
.scatter-chart { min-height: 440px; }
.scatter-chart svg { height: 440px; }
.multi-results-panel, .report-builder { margin-top: 16px; }
.multi-results-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 14px; margin-top: 14px; }
.multi-result-card { min-width: 0; padding: 16px; border: 1px solid rgba(7,59,87,.1); border-radius: 16px; background: #fff; box-shadow: var(--shadow-small); }
.multi-result-card .chart { min-height: 320px; margin-top: 10px; }
.multi-result-card .chart svg { min-width: 520px; height: 320px; }
.multi-result-card table { margin-top: 10px; }
.multi-result-conclusion { margin: 12px 0 0; padding: 11px 13px; border-left: 4px solid var(--green); border-radius: 10px; background: var(--soft); font-size: .8rem; line-height: 1.55; }
.cross-correlation-block { margin-top: 18px; padding-top: 18px; border-top: .6px solid var(--line-dark); }
.project-correlation-controls { display: grid; grid-template-columns: repeat(3, minmax(160px, 1fr)) auto; align-items: end; gap: 10px; margin-top: 13px; padding: 13px; background: var(--soft); border: .5px solid var(--line); }
.project-correlation-output { display: grid; grid-template-columns: minmax(260px, .55fr) minmax(0, 1.45fr); gap: 14px; align-items: start; margin-top: 14px; }
.report-selection-list { display: grid; grid-template-columns: repeat(3, minmax(170px, 1fr)); gap: 8px; margin-top: 14px; }
.report-choice { display: flex; align-items: center; gap: 9px; min-height: 46px; padding: 9px 11px; border: 1px solid rgba(7,59,87,.1); border-radius: 13px; background: #fff; font-size: .82rem; font-weight: 650; }
.report-choice input { width: 18px; height: 18px; accent-color: var(--green); }
.report-actions { display: flex; justify-content: flex-end; gap: 9px; margin-top: 14px; }
.results-only-report { display: none; }
.results-view-menu { display: flex; align-items: end; justify-content: space-between; gap: 16px; margin-bottom: 16px; padding: 14px 16px; border: 1px solid rgba(45,154,116,.2); border-radius: 15px; background: var(--mint-2); }
.results-view-menu label { width: min(420px, 100%); }
.results-view-menu p { margin: 0 0 10px; color: var(--muted); font-size: .76rem; }
.print-report-header { margin-bottom: 20px; padding-bottom: 12px; border-bottom: .8px solid #111; }
.print-result-block { break-inside: avoid; margin: 0 0 22px; padding: 0 0 18px; border-bottom: .6px solid #bbb; }
.print-result-block h2 { margin-bottom: 8px; }
.print-result-block .chart { min-height: 330px; }
.print-result-block .chart svg { height: 330px; }
.print-conclusion { margin: 10px 0 0; padding: 10px 12px; border-left: .8px solid #111; font-size: .86rem; line-height: 1.5; }
.footnote { margin: 17px 3px 0; color: var(--muted); font-size: .73rem; line-height: 1.5; }
.site-footer { display: flex; justify-content: space-between; gap: 18px; width: min(1580px, calc(100% - 28px)); margin: 0 auto; padding: 18px clamp(14px, 3vw, 46px) 24px; border-top: 1px solid rgba(7,59,87,.12); color: var(--muted); font-size: .75rem; line-height: 1.5; }
.site-footer strong { color: var(--ink); letter-spacing: .03em; }
.site-footer .footer-meta { display: flex; align-items: center; gap: 12px; flex-wrap: wrap; }
.site-footer .visit-counter { display: inline-flex; align-items: center; gap: 7px; padding: 7px 12px; border: .6px solid var(--line-dark); border-radius: 999px; background: rgba(255,255,255,.72); color: var(--muted); font-size: .72rem; font-weight: 900; letter-spacing: .04em; text-transform: uppercase; white-space: nowrap; }
.site-footer .visit-counter strong { color: var(--ink); font-size: .95rem; line-height: 1; letter-spacing: 0; }

.assistant-launcher { position: fixed; right: 22px; bottom: 22px; z-index: 80; width: 54px; height: 54px; display: grid; place-items: center; padding: 0; border: 1px solid rgba(255,255,255,.18); border-radius: 50%; color: #fff; background: linear-gradient(135deg, var(--navy), var(--teal)); box-shadow: 0 18px 42px rgba(5,52,57,.28); }
.assistant-launcher span { width: 38px; height: 38px; display: grid; place-items: center; border-radius: 50%; color: var(--navy); background: var(--yellow); font-family: Georgia, "Times New Roman", serif; font-size: 1.15rem; font-weight: 850; }
.assistant-panel { position: fixed; right: 22px; bottom: 22px; z-index: 81; width: min(410px, calc(100vw - 28px)); max-height: min(720px, calc(100dvh - 44px)); padding: 18px; overflow: auto; border: 1px solid rgba(7,59,87,.14); border-radius: 22px; background: #fbfdfc; box-shadow: 0 28px 80px rgba(5,52,57,.32); }
.assistant-panel[hidden] { display: none; }
.assistant-head { display: flex; align-items: flex-start; justify-content: space-between; gap: 12px; }
.assistant-head h2 { margin-top: 3px; }
.assistant-close { width: 38px; height: 38px; flex: 0 0 auto; border: 1px solid rgba(7,59,87,.12); border-radius: 50%; color: var(--navy); background: var(--soft); font-size: 1.25rem; }
.assistant-intro { margin: 10px 0 12px; color: var(--muted); font-size: .82rem; line-height: 1.5; }
.assistant-topics { display: grid; grid-template-columns: 1fr 1fr; gap: 7px; }
.assistant-topics button { min-height: 46px; padding: 8px 10px; border: 1px solid rgba(7,59,87,.12); border-radius: 12px; color: var(--ink); background: #fff; text-align: left; font-size: .76rem; font-weight: 750; }
.assistant-topics button:hover, .assistant-topics button.active { border-color: var(--green); background: var(--mint); }
.assistant-answer { margin: 12px 0; padding: 14px; border-left: 4px solid var(--green); border-radius: 12px; background: var(--soft); font-size: .84rem; line-height: 1.55; outline: none; }
.assistant-answer strong { display: block; margin-bottom: 5px; color: var(--navy); font-family: Georgia, "Times New Roman", serif; }
.assistant-answer p { margin: 0; color: var(--muted); }

@media (max-width: 1180px) {
  .workflow-overview { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .calibration-grid { grid-template-columns: repeat(3, minmax(0, 1fr)); }
  .setup-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .correlation-controls { grid-template-columns: repeat(3, minmax(0, 1fr)); }
  .chart-controls { grid-template-columns: repeat(3, minmax(0, 1fr)); }
  .figure-studio-controls { grid-template-columns: repeat(3, minmax(0, 1fr)); }
  .assay-workspace-tabs { grid-template-columns: repeat(3, minmax(130px, 1fr)); }
  .project-correlation-controls { grid-template-columns: repeat(2, minmax(160px, 1fr)); }
}
@media (max-width: 860px) {
  .overview-grid, .diagnostics-grid, .chart-grid, .analysis-grid, .correlation-output, .basis-grid, .analysis-options, .multi-results-grid, .project-correlation-output { grid-template-columns: 1fr; }
  .correlation-comparison, .correlation-conclusion { grid-column: 1; }
  .grid-footer { grid-template-columns: 1fr; }
  .grid-footer .button { justify-self: start; }
  .figure-studio-controls { grid-template-columns: repeat(2, minmax(0, 1fr)); }
}
@media (max-width: 620px) {
  .topbar { padding: 13px 14px; align-items: flex-start; }
  .topbar p { display: none; }
  .brand-mark { width: 54px; height: 40px; }
  .brand-owner { font-size: .58rem; }
  .site-footer { align-items: flex-start; flex-direction: column; }
  main { padding: 18px 10px 42px; }
  .setup-panel, .data-panel, .project-panel, .recommendation-panel, .metrics-panel, .table-panel, .chart-panel, .correlation-panel, .scientific-basis, .analysis-options-panel, .conclusion-panel, .multi-results-panel, .report-builder { padding: 14px; }
  .figure-studio { padding: 18px; }
  .section-heading, .results-title, .data-heading, .panel-title-row { align-items: flex-start; flex-direction: column; }
  .panel-title-row .figure-actions { justify-content: flex-start; }
  .grid-toolbar { justify-content: flex-start; }
  .workflow-overview, .setup-grid, .calibration-grid, .correlation-controls, .chart-controls, .figure-studio-controls, .project-correlation-controls, .assay-workspace-tabs, .report-selection-list { grid-template-columns: 1fr; }
  .project-actions, .report-actions, .topbar-actions { align-items: stretch; flex-direction: column; }
  .project-file-card { grid-template-columns: 1fr; }
  .project-file-controls { align-items: stretch; flex-direction: column; }
  .project-file-card .validation { grid-column: 1; }
  .analysis-choice-footer { grid-template-columns: 1fr; }
  .calibration-card summary { align-items: flex-start; flex-direction: column; }
  .workspace-tabs { top: 68px; }
  .workspace-menu-button { min-width: 205px; min-height: 44px; }
  .workspace-menu { width: min(270px, calc(100vw - 20px)); }
  .results-view-menu { align-items: stretch; flex-direction: column; }
  .results-view-menu label { width: 100%; }
  .results-view-menu p { margin: 0; }
  .figure-studio-controls { gap: 16px; padding: 16px; }
  .figure-studio-controls .button { width: 100%; min-width: 0; margin-top: 2px; }
  .stats-ticker { grid-template-columns: 1fr; }
  .ticker-label { min-height: 34px; justify-content: center; }
  .assistant-launcher { right: 12px; bottom: 12px; }
  .assistant-panel { right: 10px; bottom: 10px; width: calc(100vw - 20px); max-height: calc(100dvh - 20px); }
  .assistant-topics { grid-template-columns: 1fr; }
}

@media (prefers-reduced-motion: reduce) {
  .ticker-track { animation: none; transform: none; }
  .ticker-viewport { overflow-x: auto; }
  .button, .assay-tab { transition: none; }
}

@media print {
  .topbar { position: static; }
  .no-print, .setup-panel, .data-panel { display: none !important; }
  main { width: 100%; padding: 10px; }
  .results { margin-top: 0; }
  .panel { box-shadow: none; break-inside: avoid; }
  .overview-grid, .diagnostics-grid, .chart-grid, .analysis-grid { grid-template-columns: 1fr 1fr; }
  .correlation-output { grid-template-columns: .65fr 1.35fr; }
  .table-wrap, .processed-wrap, .posthoc-wrap { max-height: none; overflow: visible; }
  body.results-print-mode > .topbar, body.results-print-mode > main, body.results-print-mode > .site-footer { display: none !important; }
  body.results-print-mode > .results-only-report { display: block !important; padding: 14px; }
  body.results-print-mode .no-print { display: none !important; }
}